A new method to prepare microparticles based on an Aqueous Two-Phase system (ATPS), without organic solvents

Aqueous Two-Phase Systems (ATPS) are aqueous droplets dispersed in an phase. This specific behavior arises from interactions between at least two water-soluble entities, such as thermodynamically incompatible polymers. A simple, fast, and “green” process to produce ATPS with core would be of high interest the pharmaceutical field for drug delivery. However, date, rapid destabilization represents main hurdle their use. Herein we present a novel achieve stabilized microparticle-ATPS, without use organic solvents. composed dextran polyethylene oxide were prepared. Pickering-like emulsion technique was used stabilize by adsorbing semi-solid particles (chitosan-grafted lipid nanocapsules) interface phases. Finally, microparticles formed polyelectrolyte complexation gelation. The structure stability characterized using microscopy Turbiscan analysis. Adding chitosan-grafted nanocapsules induced stabilization. sodium alginate allowed formation gelled shell that strengthened formulation against shear stress improved long-term stability, thus demonstrating is possible form delivery systems encapsulate hydrophilic molecules.